Screening for Parkinson’s Disease with Response Time Barriers: A Pilot Study

Background: Although significant response time deficits (both reaction time and movement time) have been identified in numerous studies of patients with Parkinson’s disease (PD), few attempts have been made to evaluate the use of these measures in screening for PD. Methods: Receiver operator characteristic curves were used to identify cutoff scores for a unitweighted composite of two choice response tasks in a sample of 40 patients and 40 healthy participants. These scores were then cross-validated in an independent sample of 20 patients and 20 healthy participants. Results: The unit-weighted movement time composite demonstrated high sensitivity (90%) and specificity (90%) in the identification of PD. Movement time was also significantly correlated (r = 0.59, p \u3c 0.025) with the motor score of the Unified Parkinson’s Disease Rating Scale (UPDRS). Conclusions: Measures of chronometric speed, assessed without the use of biomechanically complex movements, have a potential role in screening for PD. Furthermore, the significant correlation between movement time and UPDRS motor score suggests that movement time may be useful in the quantification of PD severity

Origin of Disc Lopsidedness in the Eridanus Group of Galaxies

The HI surface density maps for a sample of 18 galaxies in the Eridanus group are Fourier analysed. This analysis gives the radial variation of the lopsidedness in the HI spatial distribution. The lopsidedness is quantified by the Fourier amplitude $A_1$ of the $m=1$ component normalized to the average value. It is also shown that in the radial region where the stellar disc and HI overlap, their $A_1$ coefficients are comparable. All the galaxies studied show significant lopsidedness in HI. The mean value of $A_1$ in the inner regions of the galaxies (1.5 - 2.5 scale lengths) is $\geq 0.2$. This value of $A_1$ is twice the average value seen in the field galaxies. Also, the lopsidedness is found to be smaller for late-type galaxies, this is opposite to the trend seen in the field galaxies. These two results indicate a different physical origin for disc lopsidedness in galaxies in a group environment compared to the field galaxies. Further, a large fraction ($\sim$ 30%) shows a higher degree of lopsidedness ($A_1 \geq 0.3$). It is also seen that the disk lopsidedness increases with the radius as demonstrated in earlier studies, but over a radial range that is two timeslarger than done in the previous studies. The average lopsidedness of the halo potential is estimated to be $\sim 10$%, assuming that the lopsidedness in HI disc is due to its response to the halo asymmetry.Comment: 10 pages, 5 figures, Accepted for publication in MNRA

Design and Analysis of Soft-Error Resilience Mechanisms for GPU Register File

Modern graphics processing units (GPUs) are using increasingly larger register file (RF) which occupies a large fraction of GPU core area and is very frequently access ed. This makes RF vulnerable to soft-errors (SE). In this paper, we present two techniques for improving SE resilience of GPU RF . First, we propose compressing the RF values for reducing the number of vulnerable bits. We leverage value similarity and the presence of narrow-width values to perform compression at warp or thread-level, respectively. Second, we propose sel ective hardening to design a portion of register entry with SE immun e circuits. By collectively using these techniques, higher r esilience can be provided with lower overhead. Without hardening, our warp and thread-level compression techniques bring 47.0% and 40.8% reduction in SE vulnerability, respectively

A Magellanic Origin for the Warp of the Galaxy

We show that a Magellanic Cloud origin for the warp of the Milky Way can explain most quantitative features of the outer HI layer recently identified by Levine, Blitz & Heiles (2005). We construct a model similar to that of Weinberg (1998) that produces distortions in the dark matter halo, and we calculate the combined effect of these dark-halo distortions and the direct tidal forcing by the Magellanic Clouds on the disk warp in the linear regime. The interaction of the dark matter halo with the disk and resonances between the orbit of the Clouds and the disk account for the large amplitudes observed for the vertical m=0,1,2 harmonics. The observations lead to six constraints on warp forcing mechanisms and our model reasonably approximates all six. The disk is shown to be very dynamic, constantly changing its shape as the Clouds proceed along their orbit. We discuss the challenges to MOND placed by the observations.Comment: 4 pages, 3 figures, submitted to ApJ Letters. Additional graphics, 3d visualizations and movies available at http://www.astro.umass.edu/~weinberg/lm

Electrode Heating in a Wire-to-Plane Arc

A steady wire-to-plane electric discharge has been modeled in a prolate spheroidal coordinate system with the wire shape taken as a hyperboloid of revolution. A set of continuum conservation equations for the charged particle densities and temperatures together with Poisson’s equation for the self-consistent electric potential describe the steady electric discharge process. These equations have been solved numerically to obtain ion and electron densities, temperature distribution, and electrode heat fluxes. Particle densities show the main body of the arc is quasineutral bounded by space charge sheaths at both electrodes. The temperature is greatest in a region around the discharge axis about one-third of the distance from the wire to the plane. Strong electric fields are concentrated in the electrode sheaths. The heat flux to the wire is sharply peaked near the tip but on the plane it decays slowly away from the discharge axis. The knowledge of heat transfer from the arc to the electrodes is useful in determining arc parameters that govern the ball formation process used in wire bonding of microelectronic semiconductor chips as well as welding processes

Breakdown of a Wire-to-Plane Discharge: Transient Effects

A wire-to-plane discharge during the early phases of breakdown has been studied. The discharge has been modeled in a prolate spheroidal coordinate system with the wire shape taken as a hyperboloid of revolution. Four simultaneous coupled, time-dependent, nonlinear partial differential equations describe the electrical discharge. These are the conservation equations for ion and electron densities, the energy equation for electron temperature, and Poisson’s equation for the self-consistent electric field. By solving this formulation subject to appropriate initial and boundary conditions, charged particle densities and temperature variations have been obtained as the ionization progresses in the discharge. The results show that both the electron temperature and the charged particle densities increase with the progress of ionization. The effect of different wire polarities is also examined. With a positive wire polarity, the increases in electron temperature and charged particle densities are confined to regions of the discharge in the vicinity of the wire tip. With a negative wire polarity, the breakdown occurs in the entire gap at a faster rate than with a positive wire polarity. The wire polarity affects the magnitude of energy transfer between the particles